Phosphoinositide Lipid Phosphatases: Natural Regulators of Phosphoinositide 3-Kinase Signaling in T Lymphocytes
نویسندگان
چکیده
منابع مشابه
Regulation of Diacylglycerol Kinase by Phosphoinositide 3-Kinase Lipid Products*
Diacylglycerol kinase (DAGK ), like all type I DAGKs, has calcium regulatory motifs that act as negative regulators of enzyme activity and localization. Accordingly, DAGK is activated by phospholipase C-coupled receptors in a calcium-dependent manner. One of the first functions attributed to DAGK in lymphocytes was that of regulating interleukin 2-induced cell cycle entry. Interleukin-2 nonethe...
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The phosphatidylinositol 3-kinase signaling pathway plays a central role in regulating the host inflammatory response. The net effect can either be pro- or anti-inflammatory depending on the system and cellular context studied. This paper focuses on phosphatidylinositol 3-kinase signaling in innate and adaptive immune cells of the intestinal mucosa. The role of phosphatidylinositol 3-kinase sig...
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Phosphoinositide 3-kinases (PI3Ks) phosphorylate the 3'-OH position of the inositol ring of inositol phospholipids, producing three lipid products: PtdIns(3)P, PtdIns(3,4)P(2) and PtdIns(3,4,5)P(3). These lipids bind to the pleckstrin homology (PH) domains of proteins and control the activity and subcellular localisation of a diverse array of signal transduction molecules. Three major classes o...
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Phosphoinositide 3-kinase (PI3K) is an enzyme that participates in a myriad of cellular processes and whose activity has been linked to cell growth and transformation, differentiation, motility, insulin action, and cell survival to name a few. Direct links between PI3K action and human diseases have also been made, most notably in cancer. Thus it is not surprising that considerable effort has g...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2008
ISSN: 0021-9258
DOI: 10.1074/jbc.r700044200